Endocrine Abstracts

Obesity affects on the composition of bile: the lithogenicity of bile increases, biliary sludge and cholelithiasis are developing. Under the influence of the active form of oxygen, abnormal forms of bile acids are formed, which negatively affects the development and progression of the pathological process. With the development of inflammation in the liver and pancreas, disturbances in the membrane proteins of glucose transporters occur, the activity of nuclear receptors for th...

We have interviewed 246 people aged 18–55 years: 126 with DM type 2 with a duration of more than 5 years; 120 – without DM. The median body mass index (BMI) was 28.81 (23.51; 32.65) kg/m2: at DM – 29.12 (24.48; 33.35); without DM – 27.92 (22.85; 31.26). The presence of DM didn’t show any differences in eating behavior (DEBQ questionnaire) in contrast to BMI and gender. The emotiogenic style has become the leading one, the incentive for food ...

Background: Corticosteroid-binding globulin (CBG) plays a critical role in regulating glucocorticoid bioavailability. During inflammation, plasma CBG behaves as an acute phase “negative” protein due to the down-regulation of hepatic SerpinA6 (Cbg) expression and proteolytic cleavage of CBG. CBG contains a protease-cleavage domain (RCL) that promotes the release of CBG-bound steroids at sites of inflammation. Using an established adjuvant induced art...

Introduction: The long-term follow-up of the patients with well-differentiated thyroid cancer (WDTC) includes the monitoring of suppressive levothyroxine therapy. Our study evaluated the peculiarities of thyroid status in WDTC patients on the doses of levothyroxine leading to TSH suppression (lower than 0.5 mI/l).Study design: We have studied 114 patients with WDTC, 24 men and 90 women. The follow-up was a least 10 years after thyroid surgery, mean age a...

Introduction: Condition of injected skin and subcutaneous tissue is assessed by visual inspection and palpation and it has only 10–15% diagnostic value. The standard ultrasonography comparison of symmetrical skin areas is not valuable as they are usually used for injections.Objective: We examined 143 patients, aged 43.3 ± 3.9 years, with DM duration of 6.5 ± 2.8 years, receiving basal-bolus insulin therapy.Methods: ...

Retinol binding protein (RBP) is an adipokine, related to insulin resistance (IR). Excess free fat acid reduces the binding of insulin by hepatocyte receptors and leads to hyperinsulinemia. RBP transport protein synthesized in hepatocytes and adipocytes. The level of RBP increases in patients with obesity, diabetes and non-alcoholic fatty liver disease (NAFLD). It is positively correlated with the degree of severity of the inflammatory process and fibrosis. The RBP regulates t...

Methylglyoxal (MG) damages arginine protein residues, inhibits enzymes, disrupts insulin signal transmission, and plays a key role in the development of insulin resistance and hyperglycemia. High glucose levels cause an increase in glycation and methylglyoxal formation. Glycation is the main cause of protein damage, leading to the production of free radicals and causing inflammation.The purpose of the study: To Identify the relationship of methylglyoxal ...

Objective: To study the dynamics of cytolysis and carbonyl stress (methylglyoxal (MG)) in patients with type 2 diabetes mellitus (DM2) and non-alcoholic fat disease liver (NAFLD) on the background of various hypoglycemic therapy.Materials and methods: The study included 48 patients, 53.8 ± 11.14 years, with SD2 and NAFLD and 20 people in the control group. Viral hepatitis was excluded, toxic and drug-induced liver injury. Anthropometric researc incl...

Glycation is due to the ability of glucose to form irreversible chemical compounds with amino groups of lysine and arginine – methylglyoxal (MG).Material and Methods: 98 patients with NAFLD and 52 patients with NAFLD were examined. Diabetes 2-type, and 22 healthy volunteers. Age 57.3 ± 5.2 years. BMI 34.85 ± 1.79. The diagnosis was established on the basis of laboratory data and examination results. The level of LPO was determinedby the c...

Background: It is recognized worldwide that the endocrine diseases lead among the causes of secondary osteoporosis. Based on many studies there was established the frequency of osteoporosis during the thyroid disorders, diabetes mellitus, hypercorticism. The most obscure in this line is the metabolic syndrome. The study of bone mineral density index during the metabolic syndrome is interesting from the aspect that until now the obesity has been considered to be the prevention ...